Wed. Oct 15th, 2025


So, which is the best weight loss injection in the UK?

There’s no one-size-fits-all answer – the best weight loss injection is the one that works for you and allows you to make long-term lifestyle changes that help you keep weight off after stopping the medication.

Knowing which weight loss injection is best means taking into consideration things like dosage schedule, availability and side effects.

Daily vs. weekly

Weight loss medications can have different dosing instructions, which suit different people.

For example, some people prefer the routine of taking medication every day, like Saxenda, while others prefer taking it less frequently, like Wegovy’s weekly dosage schedule. 

Which dosing schedule would suit you best? 

NHS availability

Each injection has different availability on the NHS. 

So, comparing Mounjaro and Wegovy, while Mounjaro achieved the best weight loss results in clinical tests, Wegovy is more readily available via the NHS

And accessing weight loss injections through the NHS or an NHS partner is typically best. That’s because, not only does it help make it more affordable, but it also means you’ll get medical supervision throughout your treatment which is key to getting the most out of it safely. 

Side effects

Side effects can vary from person to person, so the best weight loss injection for you may be different to someone else. 

Wegovy, Saxenda and Ozempic are all GLP-1 agonists, meaning they target the GLP-1 hormone produced by the body after eating. 

Mounjaro, on the other hand, is a dual agonist of GIP and GLP-1, targeting two hormones

So, while the most common side effects for all four medications are similar, how they impact people can vary. 

Each medication comes with its own contraindications too, which is why it’s so important to be medically assessed rather than buying online.



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